The church is located close to the Porta del Santo gate and is a sanctuary of considerable importance in the Samnite hinterland. It is built according to a Latin cross layout divided into three naves, off which open the side chapels. The central nave and the transept are covered by false ceiling trusses which are decorated with fine paintwork.
Inside the church are paintings by Paolo De Matteis (1662-1728) depicting the Triumph of San Rocco (from the church of the same name) and The Annunciation (coming from the church of the Annunciation).